Nitric oxide (common name) or nitrogen monoxide (systematic name) is a chemical compound with chemical formula NO. This diatomic gas is an important cell signaling molecule in mammals, including humans, and is an extremely important intermediate in the chemical industry. It is also an air pollutant produced by combustion of substances in air, like in automobile engines and fossil fuel power plants.
In mammals, NO is an important cellular messenger molecule involved in many physiological and pathological processes. Low levels of NO production are important in protecting an organ such as the liver from ischemic damage. However, sustained levels of increased NO production result in direct tissue damage and contribute to the vascular collapse associated with septic shock, whereas chronic expression of NO is associated with various carcinomas and inflammatory conditions including juvenile diabetes, multiple sclerosis, arthritis and ulcerative colitis.
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